What is Effect Excess Vitamin C?

What is effect excess vitamin C? we know if the lack of vitamin C can cause the body to dry, sore throat etc.. But right now it is common vitamin C supplement products in excess of the amount needed by the body. Is excessive consumption of vitamin C are negative effects to the body or not?

Recommended dose vitamin C for adults is 90 mg / day for men and 75 mg / day for women. The dose was not sufficient to smokers because of the negative effects caused by cigarette smoke. It is therefore recommended vitamin C was increased to 125 mg for men and 110 mg for women. This figure is slightly higher in order to protect the body against the harmful effects of tobacco smoke, so it stays in the blood levels obtained were similar to adults who do not smoke.

How about the consumption of high doses of vitamin C as there are many supplements on the market in the preparation? The initial idea of ​​the use of high doses of vitamin C because some books say that the easiest way for the body to absorb vitamin C is in pill form, and recommend the use of vitamin C as a treatment neutraceutical to protect against flu and cancer, making people compete use of vitamin C in large doses up to 4000 mg / day.

This led researchers interested in conducting research into the use of high doses of vitamin C. Apparently effect arising from the use of vitamin C dose of 2 grams is the change in insulin response to carbohydrate metabolism. Another undesirable effect such as indigestion, nausea, stomach cramps, excessive gas, and diarrhea.

Several studies that have been published stating that the consumption of vitamin C which is beneficial at doses 100-300 mg / day. Vitamin C in the form of a vitamin C ester which has been esterified to fatty acids, so that it becomes a form of vitamin C that is fat soluble. The aim is to facilitate the entry of vitamin C into the cells.

However, vitamin C obtained from fruits more readily available vitamin C is the best and always safe to use.

Effective Combination Therapy for Breast Cancer

Medical efforts to cure breast cancer, find the type of effective combination therapy for breast cancer. Therapy with a combination of chemotherapy medicines known antibody significantly extend survival of breast cancer patients who have this type of cancer cell HER-2 positive.

Combining trastuzumab combination therapy that is HER-2 receptor antibody with chemotherapy drugs emtansine. By promising therapies that improve the life expectancy of patients more than standard cancer treatment.

According dr.Arya Wibitomo, head of medical management PT.Roche Indonesia, combination therapy has the advantage of cancer cell killing power is high.

Trastuzumab emtansine is designed to attack and inhibit HER-2 signal and continue chemotherapy directly to the cancer cells with HER-2 positive status. Thus the spread of cancer cells can be prevented.

"The therapy may be referred to as a smart bomb because the target is not on healthy cells. Study results showed increased levels of quality of life of patients and worsening of the disease can be reduced," he said in the presentation of research results EMILIA in Jakarta, Thursday (08/30/12) .

According dr.Dradjat R.Suardi, Sp.B-Onk, examination or cancer cell receptors called immuno histochemistry checks are now a standard procedure in the diagnosis of cancer. The diversity of types of breast cancer necessitate diagnostic detail before deciding which type of therapy will be used.

The patient is said to HER-2 positive if the tumor is found over expression of HER2 and is less sensitive to a particular chemotherapy. Of overall breast cancer patients, about 25 percent have a positive HER-2 receptor is the most vicious.

"In the future treatment will be adjusted on the receptor. Breast cancer patients with HER-2 positive cancer usually the most aggressive because cancer cells have receptors for growth hormone catch," said dr.Dradjat, chief of cancer prevention in RS.Hasan Sadikin, Bandung.

Added dr.Dradjat current cancer treatment with targeted therapy and increased life expectancy of the patient. Government through ASKES has guaranteed reimbursement of cancer medicines.

Apparently Grapefruit Orange Can Helpful Absorption Medicines

There is a way that absorption properties of medicine in body tissues more leverage. Apparently Grapefruit orange can helpful absorption medicines.

Grapefruit can inhibit the enzyme in the intestinal wall that slow the entry of the drug into the bloodstream. Consumption of grapefruit with medicines for cholesterol (statins), psychiatry (valium, zoloft), pain reduction (methadone), and cancer drug (sirolimus / rapamycin) causes the drug gets into the bloodstream faster so be poison in the body of the patient.

A recent study by researchers at the University of Chicago Medicine (UCM), the United States, finding the positive side of grapefruit. Consumption of citrus fruits can reduce the dose of sirolimus to minimize the side effects of drugs.

The study, reported in the journal Clinical Cancer Research and quoted by LiveScience, Tuesday (7/8) and then, led by cancer expert UCM, Ezra Cohen. The study involved 138 cancer patients were divided into three groups.

The result, which only needs to take sirolimus dose 90 mg per week. Who drank grapefruit juice only need 25-35 mg of sirolimus per week. Sirolimus and ketoconazole groups need 16 mg of sirolimus per week. However, grapefruit juice is recommended because it is natural and inexpensive